An editorial notes the study comes with certain limitations. One is ascertainment bias, i.e. are the results specific to the infection exposure, or are they the outcome of participants being in greater contact with medical practitioners (and thus experiencing increased monitoring). It adds that the results of the study leave a number of pressing questions; since it controlled for important confounders and validated the findings in a sibling cohort, the results may reflect a causative biological mechanism. It asks what this mechanism could be, and more importantly, could the incidence of debilitating childhood neuropsychiatric disorders be reduce by targeting infection?