An editorial suggests that the reassuring message for clinicians and women who are taking antidepressants and planning pregnancy or who are pregnant was that more than 95% of women in the study who took antidepressants did not have a child with autism spectrum disorder. It notes that the study estimated that even if the association between antidepressant use and autism is causal, and with all other factors equal, then only 2% of cases would be prevented if no women with psychiatric disorders used antidepressants during pregnancy. It adds that although such a small risk within a population might seem too high from an individual’s perspective, it must be carefully weighed against the substantial health consequences associated with untreated depression.