In 2006, the US FDA cautioned about off-label use of quinine for idiopathic muscular cramps, citing “665 reports of adverse events with serious outcomes…including 93 deaths.” Despite warnings, quinine is still prescribed to individuals for cramps. Furthermore, many drinks such as bitter lemon or tonic waters contain quinine, and hence, many people may be exposed to quinine daily. The researchers warn that the benefits of quinine in reducing cramps should be balanced against the risks.