Among 3315 women exposed to oral fluconazole from 7 through 22 weeks gestation, 147 experienced a spontaneous abortion, compared with 563 among 13,246 unexposed matched women (HR 1.48; 95% CI, 1.23-1.77). The researchers advise that until more data on the association are available, cautious prescribing of fluconazole in pregnancy may be advisable.
According to the UK Teratology Information Service, fluconazole is not recommended for use during pregnancy. However, vaginal candidiasis is common in pregnancy, and as fluconazole is sometimes prescribed to treat candidiasis that has not responded to topical clotrimazole treatment, exposure during pregnancy is not uncommon.