Association of Antioxidant Supplement Use and Dementia in the Prevention of Alzheimer’s Disease by Vitamin E and Selenium Trial (PREADViSE) -

Association of Antioxidant Supplement Use and Dementia in the Prevention of Alzheimer’s Disease by Vitamin E and Selenium Trial (PREADViSE)
Information type: Other primary research
Source: JAMA Neurology
Specialities: Complementary and alternative therapies | Later life | Neurological disorders
Summary
Study (n=7540) found no difference in dementia incidence in asymptomatic men amongst the four treatment arms; vitamin E, selenium, the combination of both and placebo. The study concluded that neither supplement prevented dementia.
UKMi comment
An editorial discusses the complications which arise with prevention trials in Alzheimer’s disease, noting some of the studies which have been completed in this arena to date. It discusses the difficulties undertaking prevention trials, which include the following “…uncertainty of medication dose, mechanisms of action, and proof of target engagement; proper selection of a diverse population that can be observed for a realistic period to yield enough cases of dementia to determine success or failure of the intervention; use of appropriate assessment tools and methods of accurate diagnosis; and use of effective ways for maintaining participation and assuring adherence in the study over time. “
Related links: Editorial