Association of High Intakes of Vitamins B6 and B12 From Food and Supplements With Risk of Hip Fracture Among Postmenopausal Women in the Nurses’ Health Study

Study (n=75,864) reports that during follow up from 1984 to 2014; a combined high intake of vitamins B6 and B12 was associated with an increased risk of hip fracture. The intakes were far higher than the recommended dietary allowances.

Both vitamin B6 (RR, 1.29; 95% CI, 1.04-1.59 for an intake of ≥35 vs <2 mg/d; p = 0.06) and vitamin B12 (RR, 1.25; 95% CI, 0.98-1.58 for an intake of ≥30 vs <5 μg/d; p= 0.02) were associated with increased fracture risk.

Authors were not able to provide a possible biological explanation for the findings in this study, but warn that vitamin supplementation far exceeding recommended doses is associated with adverse effects.