Association of Initiation of Basal Insulin Analogs vs Neutral Protamine Hagedorn Insulin With Hypoglycemia-Related Emergency Department Visits or Hospital Admissions and With Glycemic Control in Patients With Type 2 Diabetes

Retrospective study (n=25 489) found that initiation of basal insulin analogs vs NPH insulin was not associated with reduced risk of hypoglycaemia-related A&E visits or hospital admissions (11.9 vs 8.8 events per 1000 person-years), and rates did not differ in adjusted analyses.

The authors note their findings suggest that the use of basal insulin analogs in usual practice settings may not be associated with clinical advantages for these outcomes.

 

A related editorial discusses the implications of these findings including reemphasising NPH insulin as a front-line insulin option for most patients with type 2 diabetes.