An editorial notes that though the researchers present powerful data on a large number of women in a very clear fashion, they also rely on data with extensive missing values, make assumptions about underlying disease burden that cannot be verified, and acknowledge that their estimates are imprecise. It suggests that rather than focusing on statistical issues and study design, there should be a move towards agreeing that overdiagnosis does occur, even though the exact percentage of overdiagnosed cases remains unknown. It adds that no single approach will adequately address the issue, but one way to reduce overdiagnosis is targeted, precision screening of persons who have a higher risk of breast cancer rather than screening large populations in which the majority of persons are at a lower risk for harmful disease.