Cannabis users required a mean of 125.93 μg of fentanyl, 9.15 mg of midazolam, and 44.81 mg of propofol compared with nonusers (109.91 μg of fentanyl, 7.61 mg of midazolam, and 13.83 mg of propofol, respectively). Compared with nonusers, cannabis users required 14% more fentanyl, 19.6% more midazolam, and 220.5% more propofol for the duration of the endoscopic procedure.