Individualised prediction of alternate-day aspirin treatment effects on the combined risk of cancer, cardiovascular disease and gastrointestinal bleeding in healthy women -

Individualised prediction of alternate-day aspirin treatment effects on the combined risk of cancer, cardiovascular disease and gastrointestinal bleeding in healthy women
Information type: Other primary research
Source: Heart
Specialities: Cardiovascular system disorders
Summary
Concurrent evaluation of absolute effects on cancer, CVD and major GI bleeding using a risk model applied to long term follow-up data on 27,939 healthy women found that alternate-day use of low-dose aspirin is ineffective or harmful in the majority of women in primary prevention.
UKMi comment
An editorial notes that when balancing combined long-term aspirin benefits on CVD and cancer with its harmful effects, taking into account the individual risk profile for each investigated outcome, these results support no treatment indications with alternate-day low-dose aspirin in healthy women. The authors call for further evidence in subjects at high CVD risk or with metabolic syndrome, and suggest that another path of future research is to improve risk estimation through new biomarkers that could help identify men and women at high risk more accurately.
Related links: Editorial