Long-Term Weight Loss With Metformin or Lifestyle Intervention in the Diabetes Prevention Program Outcomes Study -

Long-Term Weight Loss With Metformin or Lifestyle Intervention in the Diabetes Prevention Program Outcomes Study
Information type: Other primary research
Source: Annals of Internal Medicine
Specialities: Diabetes | Nutritional and metabolic disorders
Summary
This post-hoc analysis (n=3234) reports in those with weight loss of >5% after 1 year, those originally randomised to metformin had the greatest loss during years 6 to 15 compared to those randomised to intensive lifestyle interventions (ILS) or placebo.
UKMi comment

Among participants who lost at least 5% of their baseline weight during year 1, initial weight loss was greatest in the ILS group (11.0% vs. 8.9% in the metformin group and 9.2% in the placebo group); at year 6 and beyond, the percentage who maintained weight loss greater than 5% was lower in the ILS group (43%) than in the metformin group (56%).

Several limitations have been identified, including the number of participants in the ILS and placebo groups who received metformin increased over time - by year 15, 37% of those in the placebo group had been treated with metformin. Of note, only 72% of participants in the metformin group were adherent (defined as taking ≥80% of the assigned dose).
Related links: Editorial