Metformin-associated lactic acidosis precipitated by liraglutide use: adverse effects of aggressive antihyperglycaemic therapy -

Metformin-associated lactic acidosis precipitated by liraglutide use: adverse effects of aggressive antihyperglycaemic therapy
Information type: Other primary research
Source: Drug and Therapeutics Bulletin
Specialities: Diabetes | Later life
Summary
Case was a 70-year-old man with metformin-associated lactic acidosis (MALA). Liraglutide can precipitate MALA if taking metformin concomitantly as it often causes nausea and vomiting, which can lead to dehydration and acute kidney injury; risk factors for MALA.
UKMi comment
MALA is a rare, life-threatening adverse effect of metformin. Authors advise we must be cautious about using aggressive anti-hyperglycaemic therapy among elderly patients with type 2 diabetes because of the elevated risk of adverse drug interactions in this vulnerable population.
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