Pre-Pregnancy Diabetes and Offspring Risk of Congenital Heart Disease: A Nation-Wide Cohort Study -

Pre-Pregnancy Diabetes and Offspring Risk of Congenital Heart Disease: A Nation-Wide Cohort Study
Information type: Other primary research
Source: Circulation Research
Specialities: Cardiovascular system disorders | Diabetes | Obstetrics and gynaecology
Summary
This cohort study (n=2,025,727) found that maternal pre-gestational diabetes profoundly increased offspring CHD risk (adjusted RR= 4.00 95%CI= 3.51-4.53) and that the association was not modified by year of birth, maternal age at diabetes onset, or diabetes duration.
UKMi comment
An editorial discusses this research highlighting that these findings underscore the fact that today pre-gestational diabetes is an important modifiable risk factor for CHD as well as for other birth defects.
Related links: Editorial