A commentary notes that although this study might not disentangle the underlying pathological changes in patients with treatment-resistant schizophrenia, it contributes by defining obstacles between health-care providers and patients in need. It calls for the removal of all hurdles that prevent patients from gaining access to treatment. To achieve this, it recommends the provision of early detection and intervention services, as well as innovative pharmacological research to investigate beyond the modulation of the dopaminergic and serotonergic systems, and treatment interventions that offer more flexible follow-up interventions such as house calls and outpatient care after an initial hospital admission.