The systematic review included 9 controlled trials, 55 patients on non-selective beta-blocker eye drops and 33 patients on selective beta-blocker eye drops. The meta-analysis found acute non-selective beta-blocker eye drop exposure caused significant mean falls in FEV1 of −10.9% (95% CI −14.9 to −6.9), and falls in FEV1 of ≥20% affecting one in three. Corresponding values for selective beta-blockers in people sensitive to ocular non-selective beta-blockers was −6.3% (95% CI −11.7 to −0.8), and a non-significant increase in falls in FEV1 of ≥20%.