An editorial advises vegetarians and others to keep the reported stroke risk in perspective, as it is based on results from just one study, and the increase is modest relative to meat eaters: “equivalent to three more cases of total stroke (95% CI, 0.8 to 5.4 more) per 1000 population over 10 years.” It adds that when interpreting these results, any plausible dietary mediators of the association between vegetarian diets and stroke should be considered. Furthermore, vitamin B12 is considered a nutrient at risk in some vegetarian diets, unless fortified foods and supplements are used, and the role of suboptimal intake of B12 in stroke risk is unclear, and further exploration should include re-evaluation of existing vitamin B trials and mechanistic studies to support observational evidence. It highlights that dietary guidelines contain the most evidence informed advice available for vegetarians, as well as for fish and meat eaters, and they consider dietary associations with multiple health outcomes—not just ischaemic heart disease and stroke—alongside nutritional adequacy; a dietary outcome of particular importance to vegetarians.