Combined immunosuppression and radiotherapy in thyroid eye disease (CIRTED): a multicentre, 2 × 2 factorial, double-blind, randomised controlled trial -

Combined immunosuppression and radiotherapy in thyroid eye disease (CIRTED): a multicentre, 2 × 2 factorial, double-blind, randomised controlled trial
Information type: Randomised controlled trials
Source: The Lancet Diabetes & Endocrinology
Specialities: Endocrine system disorders | Eyes and vision
Summary
2x2 factorial RCT (n=126) found that in patients receiving oral prednisolone for 24 weeks, radiotherapy and/or azathioprine did not have added benefit. Authors report that conclusions are limited by the high number of patients who withdrew from treatment.
UKMi comment

A related commentary discusses this research. On the basis of the results of this study, neither radiotherapy nor azathioprine should be regarded as first-line treatment options in Graves' orbitopathy.
Related links: Commentary