Comparative evaluation of quetiapine plus lamotrigine combination versus quetiapine monotherapy (and folic acid versus placebo) in bipolar depression (CEQUEL): a 2×2 factorial randomised trial -

Comparative evaluation of quetiapine plus lamotrigine combination versus quetiapine monotherapy (and folic acid versus placebo) in bipolar depression (CEQUEL): a 2×2 factorial randomised trial
Information type: Randomised controlled trials
Source: The Lancet Psychiatry
Specialities: Mental health and illness
Summary
RCT (n=202) found addition of lamotrigine (vs. placebo) to quetiapine treatment improved outcomes at 12 weeks [mean difference in Quick Inventory of Depressive Symptomatology—self report version 16 total score:−1.73; p=0.066). Folic acid seemed to nullify effect of lamotrigine.
UKMi comment
According to a commentary, the findings from CEQUEL, although interesting and clinically relevant, still need replication and corroboration from both randomised controlled trials and empirical research.
Related links: Comment