A related editorial discusses this research, and treatment considerations for patients with AF undergoing PCI. It concludes that the overall evidence supports dual antithrombotic therapy rather than triple antithrombotic therapy as the best option for this population of patients with atrial fibrillation who have had PCI when concerns about bleeding prevail over concerns about stent thrombosis, a scenario that affects most patients in need of combined treatment with oral anticoagulant and antiplatelet therapy.