Effect of 2 Years of Treatment With Sublingual Grass Pollen Immunotherapy on Nasal Response to Allergen Challenge at 3 Years Among Patients With Moderate to Severe Seasonal Allergic Rhinitis: The GRASS Randomized Clinical Trial -

Effect of 2 Years of Treatment With Sublingual Grass Pollen Immunotherapy on Nasal Response to Allergen Challenge at 3 Years Among Patients With Moderate to Severe Seasonal Allergic Rhinitis: The GRASS Randomized Clinical Trial
Information type: Randomised controlled trials
Source: Journal of the American Medical Association
Specialities: Allergy and immunology | Ear, nose and throat disorders | Paediatric and neonatal medicine
Summary
RCT (n=106) found that 2 years of sublingual grass pollen immunotherapy was not significantly different from placebo in improving total nasal symptoms scores following allergen challenge (baseline adjusted treatment difference = -0.18, p=0.75).
UKMi comment
A related commentary highlights that current evidence and clinical guidelines recommend at least 3 years of sublingual immunotherapy (SLIT). The data from this study suggest that 2 years treatment is not sufficient for SLIT to induce long-term clinical efficacy. The study provides an important contribution to the evidence regarding immunotherapy for allergic rhinitis. With the emergence of SLIT over the past decade, it is important to clearly define the duration of therapy necessary to improve symptoms and clinical outcomes for patients with allergic rhinitis.
Related links: Commentary