A related commentary discusses this research. While it is encouraging that capsules appear to be a viable delivery route for faecal microbiota transplantation (FMT), a number of additional approaches still deserve consideration in future research. These include vancomycin tapers with and without “chasers” of fidaxomicin/ rifaximin, defined microbial communities, and sterile faecal derived products. If these latter approaches prove to be effective, they may supplant standard FMT and other undefined microbial consortia, making even convenient, capsule based FMT a tough pill to swallow.