A related editorial discusses the findings of this study, highlighting that it may be first appropriate to improve the detection of nonadherence rather than making the case for the above interventions. It suggests that “Innovations in e-prescribing have made it possible to leverage pharmacy fill data such that clinicians can identify nonadherent patients at the point of care. Targeting intensive behavioural adherence interventions at high-risk nonadherent patients may be an approach to achieving value, together with streamlining medications to avoid unnecessary or outdated prescriptions and using once-daily dosing whenever possible.”