Efficacy and tolerability of moxidectin alone and in co-administration with albendazole and tribendimidine versus albendazole plus oxantel pamoate against Trichuris trichiura infections: a randomised, non-inferiority, single-blind trial -

Efficacy and tolerability of moxidectin alone and in co-administration with albendazole and tribendimidine versus albendazole plus oxantel pamoate against Trichuris trichiura infections: a randomised, non-inferiority, single-blind trial
Information type: Randomised controlled trials
Source: The Lancet Infectious Diseases
Specialities: Infection and infectious diseases | Paediatric and neonatal medicine
Summary
This RCT (n=634) found that moxidectin plus albendazole (MA) was non-inferior to albendazole plus oxantel pamoate (AO) in reducing T trichiura burden (egg reduction rate 98.5% v 99.8%), but the cure rate with MA was lower than with AO (51% v 83%).
UKMi comment

This study was conducted in adolescents in Tanzania. The aim of the study was to assess the efficacy of moxidectin alone and in co-administrations against T trichiura infection (whipworm).
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