D-cycloserine, a partial agonist at the N-methyl-D-aspartate receptor in the amygdala, has been associated with enhanced cognitive behavioural therapy (CBT) outcome for obsessive-compulsive disorder (OCD) among adults but its effectiveness in younger people is unknown.
An editorial notes that in the context of the current literature, the results do not prove that D-cycloserine is categorically ineffective as an augmentation strategy. Rather, the D-cycloserine effect might be more complicated than initially assumed. It adds that some of the post hoc analyses suggest that the effect of D-cycloserine might depend on the success of the exposure practices and might also be moderated by the effects of antidepressants. It calls for more research on the moderators and mechanisms of D-cycloserine.