Efficacy of Oral Mixed Tocotrienols in Diabetic Peripheral Neuropathy: A Randomized Clinical Trial -

Efficacy of Oral Mixed Tocotrienols in Diabetic Peripheral Neuropathy: A Randomized Clinical Trial
Information type: Randomised controlled trials
Source: JAMA Neurology
Specialities: Anaesthesia and pain | Diabetes | Neurological disorders
Summary
In this RCT of 300 adults with diabetic peripheral neuropathy, tocotrienols administered for 1 year did not reduce the overall neuropathic Total Symptom Score (TSS chang between tocotrienols and placebo group at 12 months −0.30; 95% CI −1.16 to 0.56; P=0.49).
UKMi comment
Tocotrienols are naturally occurring subtypes of vitamin E that modulate glutamate-induced neuronal apoptosis via inhibition of the 12-lipoxygenase pathway in in vitro studies.
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