Efficacy of Vaginal Estradiol or Vaginal Moisturizer vs Placebo for Treating Postmenopausal Vulvovaginal Symptoms: A Randomized Clinical Trial -

Efficacy of Vaginal Estradiol or Vaginal Moisturizer vs Placebo for Treating Postmenopausal Vulvovaginal Symptoms: A Randomized Clinical Trial
Information type: Randomised controlled trials
Source: JAMA Internal Medicine
Specialities: Obstetrics and gynaecology
Summary
This RCT (n=302) reports no difference in efficacy between vaginal 10-μcg estradiol tablet plus placebo gel and vaginal moisturiser plus placebo tablet compared to dual placebo at reducing symptom severity or improving sexual function in postmenopausal women.
UKMi comment

A related editorial discusses these findings, advising that based on the results of this study, women and their physicians should choose the cheapest moisturiser or lubricant available, at least until new evidence arises to suggest that there is any benefit to doing otherwise.
Related links: Editorial