Low-Dose Intravenous Immunoglobulin Treatment for Long-Standing Complex Regional Pain Syndrome: A Randomized Trial -

Low-Dose Intravenous Immunoglobulin Treatment for Long-Standing Complex Regional Pain Syndrome: A Randomized Trial
Information type: Randomised controlled trials
Source: Annals of Internal Medicine
Specialities: Anaesthesia and pain
Summary
This RCT (n=103) reports low-dose immunoglobulin treatment (two infusions of IVIg 0.5 g/kg, 3 weeks apart) for 6 weeks was not effective in relieving pain in patients with moderate to severe complex regional pain syndrome (CRPS) of 1 to 5 years' duration.
UKMi comment

In a related editorial, the authors discuss the possible reasons why this study failed to show effectiveness, highlighting that the dose of IVIg used was too low, where neurologic autoimmune diseases are usually treated with doses 4 times higher.
Related links: Editorial