Microbiological efficacy of early MRSA treatment in cystic fibrosis in a randomised controlled trial -

Microbiological efficacy of early MRSA treatment in cystic fibrosis in a randomised controlled trial
Information type: Randomised controlled trials
Source: Thorax
Specialities: Infection and infectious diseases | Respiratory disorders
Summary
Small study (n=45) found MRSA eradication with a defined protocol for newly acquired MRSA demonstrated microbiological efficacy with a large treatment effect, with 82% of participants being MRSA-negative in treatment arm vs. 26% in observation arm (p<0.001).
UKMi comment

The eradication protocol was oral trimethoprim-sulfamethoxazole or if sulfa-allergic, minocycline plus oral rifampin; chlorhexidine mouthwash for 2 weeks; nasal mupirocin and chlorhexidine body wipes for 5 days and environmental decontamination for 21 days.
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