Nintedanib plus Sildenafil in Patients with Idiopathic Pulmonary Fibrosis -

Nintedanib plus Sildenafil in Patients with Idiopathic Pulmonary Fibrosis
Information type: Randomised controlled trials
Source: New England Journal of Medicine
Specialities: Respiratory disorders
Summary
RCT (n=274) found no significant difference in adjusted mean change from baseline in the St. Georges Respiratory Questionnaire at week 12 for nintendanib plus sildenafil vs nintendanib alone (-1.28 vs -0.77 points respectively, p=0.72)
UKMi comment
This trial was performed as a previous subgroup analysis of a previously published trial suggested sildenafil may provide benefits in oxygenation and gas exchange in patients with idiopathic pulmonary fibrosis.
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