Penicillin V four times daily for five days versus three times daily for 10 days in patients with pharyngotonsillitis caused by group A streptococci: randomised controlled, open label, non-inferiority study -

Penicillin V four times daily for five days versus three times daily for 10 days in patients with pharyngotonsillitis caused by group A streptococci: randomised controlled, open label, non-inferiority study
Information type: Randomised controlled trials
Source: British Medical Journal
Specialities: Ear, nose and throat disorders | Infection and infectious diseases
Summary
Swedish study (n=433) reported that penicillin V four times daily for five days, was non-inferior in clinical cure five to seven days after end of antibiotic treatment, to penicillin V three times daily for 10 days (89.6% vs 93.3%) with no differences in the number of relapses an
UKMi comment
The authors note that these findings suggest that five days of treatment could substantially reduce the total consumption of penicillin V and might be an alternative to the currently recommended 10 day regimen.
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