The benefit of minocycline on negative symptoms of schizophrenia in patients with recent-onset psychosis (BeneMin): a randomised, double-blind, placebo-controlled trial -

The benefit of minocycline on negative symptoms of schizophrenia in patients with recent-onset psychosis (BeneMin): a randomised, double-blind, placebo-controlled trial
Information type: Randomised controlled trials
Source: The Lancet Psychiatry
Specialities: Infection and infectious diseases | Mental health and illness
Summary
RCT (n=207) found that minocycline, as an adjunctive treatment to usual antipsychotic treatment, had no effect on ratings of negative symptoms, versus placebo (treatment effect difference −0·19, 95% CI −1·23 to 0·85; p=0·73).
UKMi comment
Animal and human studies suggest that minocycline has a neuroprotective effect. A related editorial discusses the limitations of this study.
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