Ursodeoxycholic acid versus placebo in women with intrahepatic cholestasis of pregnancy (PITCHES): a randomised controlled trial -

Ursodeoxycholic acid versus placebo in women with intrahepatic cholestasis of pregnancy (PITCHES): a randomised controlled trial
Information type: Randomised controlled trials
Source: The Lancet
Specialities: Liver disorders | Obstetrics and gynaecology
Summary
Study (n=605) reports ursodeoxycholic acid did not reduce adverse perinatal outcomes in women with intrahepatic cholestasis of pregnancy vs. placebo (adjusted risk ratio 0·85 [95% CI 0·62–1·15) and routine use for this condition should be reconsidered
UKMi comment
In a related commentary authors note that changes in practice might be difficult to pursue; the use of ursodeoxycholic acid in intrahepatic cholestasis of pregnancy has become very popular without formal approval.
Related links: Commentary