The alert describes situations where it is most appropriate to use estimated Glomerular Filtration Rate (eGFR) and where it is ideal to use the creatinine clearance (CrCl) using the Cockcroft-Gault formula.
Specifically, the alert advises that creatinine clearance (CrCl) should be calculated using the Cockcroft-Gault formula (see below) to determine dosage adjustments for:
•direct-acting oral anticoagulants (DOACs)
•patients taking nephrotoxic drugs (examples include vancomycin and amphotericin B)
•elderly patients (aged 75 years and older)
•patients at extremes of muscle mass (BMI <18 kg/m2 or >40 kg/m2)
•patients taking medicines that are largely renally excreted and have a narrow therapeutic index, such as digoxin and sotalol.