Restrictions for the remaining fluoroquinolones include the following:
• Avoid in patients who have previously had serious adverse effects with a fluoroquinolone or quinolone antibiotic.
• Discontinue fluoroquinolone treatment at the first sign of tendon pain or inflammation and patients should be advised to stop treatment with a fluoroquinolone and speak with the doctor in case of symptoms of neuropathy such as pain, burning, tingling, numbness or weakness so as to prevent development of potentially irreversible condition.
• Use with special caution in the elderly, patients with renal impairment and those who have had an organ transplantation as these patients are at increased risk of tendon injury.
• Avoid concomitant treatment with a fluoroquinolone and a corticosteroid.
Medications containing cinoxacin, flumequine, nalidixic acid, and pipemidic acid are not available within the UK.