Letter sent to Healthcare Professionals: Flolan® (epoprostenol) – Introduction of new sterile solvent with different pH (temporary

This letter, issued by GSK provides information on the new formulation of Flolan (with Solvent pH 12) available from 14th October 2016, with differences in storage and administration from the current formulation (with Solvent pH 10.5).

Reconstituted Flolan with pH 12 Solvent (the new formulation) is more thermostable, which eliminates the need for use of a cold pouch/ice pack during administration.

 

Flolan (with Solvent pH 10.5) should continue to be used with a cold pouch/ice pack. Failure to do so may result in possible decrease in efficacy due to drug degradation.

 

Prescribers are advised that they should make it clear to the pharmacist/homecare provider, which formulation they are requesting for the patient.