Efficacy of pharmacological therapies for the treatment of opioid-induced constipation: systematic review and network meta-analysis. -

Efficacy of pharmacological therapies for the treatment of opioid-induced constipation: systematic review and network meta-analysis.
Information type: Systematic reviews
Source: Gut
Specialities: Anaesthesia and pain | Gastrointestinal disorders
Summary
Review of 27 RCTs (n=9,149) concludes that naloxone and naldemedine appear to be the most efficacious treatments for opioid induced constipation, with naloxone associated with fewer adverse effects.
UKMi comment

Naldemidine is a peripherally-selective μ-opioid receptor antagonist currently filed for approval with the European Medicines Agency.
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