The independent predictors of intracerebral haemorrhage growth (C-index 0·78, 95% CI 0·75–0·82) were: time from symptom onset to baseline imaging, intracerebral haemorrhage volume on baseline imaging, antiplatelet use, and anticoagulant use. Addition of information about the presence of spot sign on CT angiography to the model increased the C-index by just 0.05 (95% CI 0·03–0·07).
The researchers suggest these models could guide the monitoring of patients at risk of clinical deterioration as well as the interpretation and investigation of treatment effects in randomised trials.