A commentary notes that many cancers are asymptomatic until advanced stages of disease when treatment has a minimal effect on survival, whereas with endometrial cancer, 9 out of 10 women with early-stage disease present with the symptom of postmenopausal bleeding. Prompt evaluation of uterine bleeding in postmenopausal women can lead to early diagnosis of cancer, and early treatment and increased survival. It adds that not all women with postmenopausal bleeding have endometrial cancer, and risk needs to be appropriately communicated to patients. It applauds the authors on conducting an excellent systematic review that will inform both research and clinical care delivery.