Association of Inhaled Corticosteroids and Long-Acting Muscarinic Antagonists With Asthma Control in Patients With Uncontrolled, Persistent Asthma: A Systematic Review and Meta-analysis -

Association of Inhaled Corticosteroids and Long-Acting Muscarinic Antagonists With Asthma Control in Patients With Uncontrolled, Persistent Asthma: A Systematic Review and Meta-analysis
Information type: Systematic reviews
Source: Journal of the American Medical Association
Specialities: Respiratory disorders
Summary
Meta-analysis (15RCTs, n=7122, aged >12yrs with uncontrolled, persistent asthma) shows LAMA vs placebo as an add-on therapy to inhaled corticosteroids (CS) was associated with lower risk of exacerbations requiring systemic CS (risk difference −1.7%, RR 0.67 [95% CI 0.48-0.92]).
UKMi comment

However, long-acting muscarinic antagonists (LAMAs) were not associated with greater benefits compared with long-acting β-agonists.

A related editorial discusses the implications of the findings of this study.
Related links: Editorial