Podophyllotoxin 0.5% solution first line followed by carbon dioxide laser therapy second line if anogenital warts did not clear was most likely to be considered a cost-effective use of resources at a willingness to pay of £20,000–30,000 per additional quality-adjusted life-year gained. However, the authors report that the evidence base is limited and a head-to-head RCT evaluating comparative effectiveness of interventions is required.