Effect of statins and non-statin LDL-lowering medications on cardiovascular outcomes in secondary prevention: a meta-analysis of randomized trials -

Effect of statins and non-statin LDL-lowering medications on cardiovascular outcomes in secondary prevention: a meta-analysis of randomized trials
Information type: Systematic reviews
Source: European Heart Journal
Specialities: Cardiovascular system disorders
Summary
Analysis of 19 RCTs (n=152,507) of statins, ezetimibe, PCSK9 inhibitors, or bile acid sequestrants suggests more-intensive vs. less-intensive LDL-C lowering was associated with a 19% relative risk reduction for the primary outcome, major vascular events (RR 0.81, p<0.001).
UKMi comment

The clinical benefit was significant across varying types of more-intensive treatment and was consistent for statins and non-statin agents (PCSK9 inhibitors and ezetimibe) as active (more-intensive) intervention.
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