Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40 138 bleeding patients -

Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40 138 bleeding patients
Information type: Systematic reviews
Source: The Lancet
Specialities: Emergency medicine and urgent care | Haematological disorders | Obstetrics and gynaecology | Surgery | Wounds and injuries
Summary
Meta-analysis of patient-level data from 2 RCTs in traumatic and post-partum haemorrhage. Immediate tranexamic acid improved survival by >70% (p<0.0001). Thereafter, benefit decreased by 10% for every 15 minutes delay until 3 hours, after which there was no benefit.
UKMi comment
A related comment discucces the benefits of tranexamic acid treatment suggesting earlier administration of the agent to reduce the risk of substantial bleeding from multiple causes.
Related links: Comment