Optimal dose of selective serotonin reuptake inhibitors, venlafaxine, and mirtazapine in major depression: a systematic review and dose-response meta-analysis -

Optimal dose of selective serotonin reuptake inhibitors, venlafaxine, and mirtazapine in major depression: a systematic review and dose-response meta-analysis
Information type: Systematic reviews
Source: The Lancet Psychiatry
Specialities: Mental health and illness
Summary
Review (77 published and unpublished RCTs, n=19,364) reports that for the most commonly used second-generation antidepressants, the lower range of the licensed dose achieves optimal balance between efficacy, tolerability & acceptability in the acute treatment of major depression.
UKMi comment
A related commentary highlights strengths of this review given its large-scale, methodological rigour; and re-iterates that selective serotonin reuptake inhibitors display dose-dependent beneficial effects up to the low-to-medium end of their licensed doses, and so do mirtazapine and venlafaxine.
Related links: Commentary