Oral Direct-Acting Agent Therapy for Hepatitis C Virus Infection: A Systematic Review -

Oral Direct-Acting Agent Therapy for Hepatitis C Virus Infection: A Systematic Review
Information type: Systematic reviews
Source: Annals of Internal Medicine
Specialities: Infection and infectious diseases | Liver disorders
Summary
Review (42 studies) found 6 oral direct-acting antiviral regimens showed high sustained virologic response (SVR) rates (>95%) in patients with genotype 1 infection without cirrhosis. Patients with hepatic decompensation had lower SVR rates (78% to 87%) vs. other populations.
UKMi comment
An editorial discusses the caveats associated with hepatitis C antiviral therapy which include the response rates being close but not equal to 100%, problems of access to care, and concerns regarding serious adverse events during therapy.
Related links: Editorial