Estimated Glomerular Filtration Rate, Albuminuria, and Adverse Outcomes: An Individual-Participant Data Meta-Analysis

Review of 114 global cohorts (n=27,503,1400) found lower eGFR (whether based on creatinine alone, or based on creatinine and cystatin C) and higher urine albumin to creatinine ratio were associated with higher risk of adverse outcomes, including those with mildest category CKD.

SPS commentary:

For example, those with urine albumin to creatinine ratio <10mg/g, and eGFR of 45-59mL/min/1.73m2 were at higher risk of hospitalisation vs those with an eGFR of 90-104mL/min/1.73m2 (161 vs 79 events per 1000 person-years, adjusted HR 1.3, 95%CI 1.2-1.3, excess absolute risk 22 events per 1000 person-years)

Journal of the American Medical Association