Evaluating Progestogens for Preventing Preterm birth International Collaborative (EPPPIC): meta-analysis of individual participant data from randomised controlled trials

Analysis of 31 trials (11 644 women, 16185 offspring) found vaginal progesterone and intramuscular 17-hydroxyprogesterone caproate both reduced birth before 34 weeks' gestation in high-risk singleton pregnancies. Evidence for oral progesterone is insufficient to support its use.

Source:

The Lancet