Evaluation of a Paradigm Shift From Intravenous Antibiotics to Oral Step-Down Therapy for the Treatment of Infective Endocarditis

Review (21 studies) states use of highly orally bioavailable antibiotics as step-down therapy for infective endocarditis, after clearing bacteraemia and achieving clinical stability with intravenous regimens, should be incorporated into clinical practice.


JAMA Internal Medicine