Evaluation of Chilblains as a Manifestation of the COVID-19 Pandemic

Case series (31 patients referred to a tertiary care hospital for suspected chilblains) found that in all patients with biopsy confirmed chilblains (n=22), SARS-CoV-2 RNA remained undetected; and chilblains appeared not to be directly associated with COVID-19.

SPS commentary:

Authors of this study highlight that during the COVID-19 pandemic, several cases of chilblains and other similar skin conditions have been reported in infected patients. There have been suspicions that this may be a potential manifestation of the disease. 

Authors of a related commentary state testing needs to occur in larger numbers and also at different stages of the disease to determine if a low viral load, undetectable with current methods, or the inability to mount an adequate immune response accounts for the negative SARS-CoV-2 test results in these patients. Authors recommend dermatologists be aware of the protean cutaneous findings that are possibly associated with COVID-19, even if understanding of their origins remains incomplete at this time.

A second case series by Juncal Roca-Ginés and colleagues (n=20) reports similar findings, and has been published in the same edition of this journal.


JAMA Dermatology

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Juncal Roca-Ginés et al series: