Fatal hepatotoxicity due to sevoflurane use in a paediatric patient after aortic repair: reality or fiction? A case of pharmacovigilance

Case is 1-year-old girl in Italy who had undergone previous surgery for closure of a patent ductus arteriosus, and who developed severe acute hepatitis and died after undergoing surgical repair of an aortic isthmus narrowing; general anaesthesia with sevoflurane was implicated.

European Journal of Hospital Pharmacy