Fluoxetine for adults who are overweight or obese

This review (19 RCTs; n=2216) found fluoxetine may decrease weight versus placebo (low certainty; mean difference -2.7kg across all doses; 95% CI -4 to -1.4kg; p<0.001); however low certainty evidence suggests increased risk of dizziness, drowsiness, fatigue, insomnia and nausea.

Cochrane Database of Systematic Reviews